Protein Summary

DIMT1L from Homo sapiens

Full name: dimethyladenosine transferase
Synonym: DIMT1
GI: 1143076922
Orf:
COG:
UniProt:
Structures: | |
Complex:
Enzyme type: methyltransferase
Position of modification - modification: s:1850(1518) - m6,6A
s:1851(1519) - m6,6A

Comments:

DIMT1L is responsible for N6,N6 dimethylation at positions A1850 and A1851. Enzyme is required for distinct pre-rRNA processing reactions leading to synthesis of 18S rRNA, and it has been demonstrated that in human cells, as in budding yeast, ribosome biogenesis requires the presence of the modification enzyme rather than its RNA-modifying catalytic activity.

Publications

Title Authors Journal Details PubMed Id DOI
The human 18S rRNA base methyltransferases DIMT1L and WBSCR22-TRMT112 but not rRNA modification are required for ribosome biogenesis. Zorbas C, Nicolas E, Wacheul L, Huvelle E, Heurgué-Hamard V, Lafontaine DL. Mol Biol Cell [details] 25851604 10.1091/mbc.E15-02-0073

Last modification of this entry: 2017-09-14 17:49:32.266235
Edited by a user: elapurta
Edited content: Changed comments.