Protein Summary

Trmt61B from Homo sapiens

Full name: tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial
Synonym:
GI: 222831587
Orf:
COG: COG2519
UniProt: Q9BVS5
Structures: | 2B25 |
Complex:
Enzyme type: methyltransferase
Position of modification - modification: t:58 - m1A

Comments:

Paralog of cytoplasmic Trm61A. Unlike its cytoplasmic paralog that consists of an alpha2beta2 heterotetramer formed by Trmt61A and Trmt6, Trmt61B forms a homo-oligomer (presumably a homotetramer).

Protein sequence:

MLMAWCRGPVLLCLRQGLGTNSFLHGLGQEPFEGARSLCCRSSPRDLRDG
EREHEAAQRKAPGAESCPSLPLSISDIGTGCLSSLENLRLPTLREESSPR
ELEDSSGDQGRCGPTHQGSEDPSMLSQAQSATEVEERHVSPSCSTSRERP
FQAGELILAETGEGETKFKKLFRLNNFGLLNSNWGAVPFGKIVGKFPGQI
LRSSFGKQYMLRRPALEDYVVLMKRGTAITFPKDINMILSMMDINPGDTV
LEAGSGSGGMSLFLSKAVGSQGRVISFEVRKDHHDLAKKNYKHWRDSWKL
SHVEEWPDNVDFIHKDISGATEDIKSLTFDAVALDMLNPHVTLPVFYPHL
KHGGVCAVYVVNITQVIELLDGIRTCELALSCEKISEVIVRDWLVCLAKQ
KNGILAQKVESKINTDVQLDSQEKIGVKGELFQEDDHEESHSDFPYGSFP
YVARPVHWQPGHTAFLVKLRKVKPQLN

Enzymatic activities

Reaction Substrate Type Position
A:m1A tRNA (t) Leu/ÊAA/mitochondrial 58
A:m1A tRNA (t) Ser/GCU/mitochondrial 58
A:m1A tRNA (t) Lys/unknown/cytosolic 58

Publications

Title Authors Journal Details PubMed Id DOI
Trmt61B is a methyltransferase responsible for 1-methyladenosine at position 58 of human mitochondrial tRNAs. Chujo T, Suzuki T... RNA [details] 23097428 -

Links

_PubMed_

Last modification of this entry: 2013-02-11 14:06:42.325168
Edited by a user: magda
Edited content: Changed gi, cog, position, additional_information, comments and papers.