Protein Summary

BCDIN3 from Homo sapiens

Full name: RNA cap gamma-methyltransferase
Synonym: 7SK snRNA methylphosphate capping enzyme (MePCE), Bicoid-interacting protein 3 homolog
GI: 74758999
Orf: MEPCE
COG: COG2264
UniProt: Q7L2J0
Structures: | |
Complex:
Enzyme type: methyltransferase
Position of modification - modification: n:0 - m7Gpp(pN)

Comments:

BCDIN3 is the 7SK snRNA methylphosphate capping enzyme (MePCE) present in an snRNP complex containing both RNA processing and transcription factors,

Protein sequence:

MIEMAAEKEPFLVPAPPPPLKDESGGGGGPTVPPHQEAASGELRGGTERG
PGRCAPSAGSPAAAVGRESPGAAATSSSGPQAQQHRGGGPQAQSHGEARL
SDPPGRAAPPDVGEERRGGGGTELGPPAPPRPRNGYQPHRPPGGGGGKRR
NSCNVGGGGGGFKHPAFKRRRRVNSDCDSVLPSNFLLGGNIFDPLNLNSL
LDEEVSRTLNAETPKSSPLPAKGRDPVEILIPKDITDPLSLNTCTDEGHV
VLASPLKTGRKRHRHRGQHHQQQQAAGGSESHPVPPTAPLTPLLHGEGAS
QQPRHRGQNRDAPQPYELNTAINCRDEVVSPLPSALQGPSGSLSAPPAAS
VISAPPSSSSRHRKRRRTSSKSEAGARGGGQGSKEKGRGSWGGRHHHHHP
LPAAGFKKQQRKFQYGNYCKYYGYRNPSCEDGRLRVLKPEWFRGRDVLDL
GCNVGHLTLSIACKWGPSRMVGLDIDSRLIHSARQNIRHYLSEELRLPPQ
TLEGDPGAEGEEGTTTVRKRSCFPASLTASRGPIAAPQVPLDGADTSVFP
NNVVFVTGNYVLDRDDLVEAQTPEYDVVLCLSLTKWVHLNWGDEGLKRMF
RRIYRHLRPGGILVLEPQPWSSYGKRKTLTETIYKNYYRIQLKPEQFSSY
LTSPDVGFSSYELVATPHNTSKGFQRPVYLFHKARSPSH

Enzymatic activities

Reaction Substrate Type Position
pp(pN):mpp(pN) snRNA (sn) 7SK 0

Publications

Title Authors Journal Details PubMed Id DOI
Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme. Jeronimo C, Forget D, Bouchard A, Li Q, Chua G, Poitras C, Therien C, Bergeron D, Bourassa S, Greenblatt J, Chabot B, Poirier GG, Hughes TR, Blanchette M, Price DH, Coulombe B Mol Cell [details] 17643375 -
A capping-independent function of MePCE in stabilizing 7SK snRNA and facilitating the assembly of 7SK snRNP. Xue Y, Yang Z, Chen R, Zhou Q Nucleic Acids Res [details] 19906723 -

Last modification of this entry: Feb. 4, 2014