Protein SummaryHCAP1 from Homo sapiens |
| Full name: | RNA-capping enzyme |
|---|---|
| Synonym: | HCE, mRNA 5'-triphosphatase, GTP--RNA guanylyltransferase |
| GI: | 6685628 |
| Orf: | RNGTT |
| COG: | COG5226 |
| UniProt: | O60942 |
| Structures: | | 3S24 | |
| Complex: | |
| Enzyme type: | triphosphatase, guanylyltransferase |
| Position of modification - modification: |
m:0 - m7Gpp(pN) |
Comments:
Bifunctional mRNA-capping enzyme exhibiting RNA 5'-triphosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part.Protein sequence:
|
MAHNKIPPRWLNCPRRGQPVAGRFLPLKTMLGPRYDSQVAEENRFHPSML SNYLKSLKVKMGLLVDLTNTSRFYDRNDIEKEGIKYIKLQCKGHGECPTT ENTETFIRLCERFNERNPPELIGVHCTHGFNRTGFLICAFLVEKMDWSIE AAVATFAQARPPGIYKGDYLKELFRRYGDIEEAPPPPLLPDWCFEDDEDE DEDEDGKKESEPGSSASFGKRRKERLKLGAIFLEGVTVKGVTQVTTQPKL GEVQQKCHQFCGWEGSGFPGAQPVSMDKQNIKLLDLKPYKVSWKADGTRY MMLIDGTNEVFMIDRDNSVFHVSNLEFPFRKDLRMHLSNTLLDGEMIIDR VNGQAVPRYLIYDIIKFNSQPVGDCDFNVRLQCIEREIISPRHEKMKTGL IDKTQEPFSVRNKPFFDICTSRKLLEGNFAKEVSHEMDGLIFQPTGKYKP GRCDDILKWKPPSLNSVDFRLKITRMGGEGLLPQNVGLLYVGGYERPFAQ IKVTKELKQYDNKIIECKFENNSWVFMRQRTDKSFPNAYNTAMAVCNSIS NPVTKEMLFEFIDRCTAASQGQKRKHHLDPDTELMPPPPPKRPRPLT |
Enzymatic activities
| Reaction | Substrate | Type | Position |
|---|---|---|---|
| pp(pN):p(pN) | mRNA (m) | 0 | |
| p(pN):Gpp(pN) | mRNA (m) | 0 |
Publications
| Title | Authors | Journal | Details | ||
|---|---|---|---|---|---|
| Isolation and characterization of a human cDNA for mRNA 5'-capping enzyme. | Yamada-Okabe T, Doi R, Shimmi O, Arisawa M, Yamada-Okabe H | Nucleic Acids Res | [details] | 9512541 | - |
| Cloning and characterization of two human cDNAs encoding the mRNA capping enzyme. | Tsukamoto T, Shibagaki Y, Murakoshi T, Suzuki M, Nakamura A, Gotoh H, Mizumoto K | Biochem Biophys Res Commun | [details] | 9473487 | - |
| Recombinant human mRNA cap methyltransferase binds capping enzyme/RNA polymerase IIo complexes. | Pillutla RC, Yue Z, Maldonado E, Shatkin AJ | J Biol Chem | [details] | 9705270 | - |
| Structure of the guanylyltransferase domain of human mRNA capping enzyme. | Chu C, Das K, Tyminski JR, Bauman JD, Guan R, Qiu W, Montelione GT, Arnold E, Shatkin AJ | Proc Natl Acad Sci U S A | [details] | 21636784 | - |
Links
| _Wikipedia_ |
Last modification of this entry: 2012-11-30 11:39:52.621707
Edited by a user: magda
Edited content: Changed protein_sequence and additional_information.
