CDAT8 from Methanopyrus kandleri
|Full name:||tRNA-specific cytidine deaminase|
|Structures:||| 3G8Q ||
|Position of modification - modification:||
t:8 - U
Comments:CDAT8 is responsible for C-to-U editing at position 8 in tRNA. It is composed of three domains: an N-terminal cytidine deaminase domain (CDD), a central ferredoxin-like domain (FLD), and a C-terminal THUMP domain. Works as a dimer. In Methanopyrus kandleri, only four tRNAs (tRNAGln UUG, tRNAPro GGG, tRNAPro UGG, and tRNAThr GGU) possess a U8 (T8 in the tRNA gene), whereas the other 30 tRNA genes encode C8. The highly conserved U8 in tRNAs forms a reverse Hoogsteen tertiary base pair with A14 that stabilizes the sharp kink between the acceptor stem and base A9. The C8 must be modified to U in order to support the tertiary interaction with A14, which is present in all 34 tRNAs.
|A-to-I and C-to-U editing within transfer RNAs.||Su AA, Randau L||Biochemistry (Mosc)||[details]||22022967||-|
|Determinants of tRNA editing and modification: Avoiding conundrums, affecting function.||Paris Z, Fleming IM, Alfonzo JD||Semin Cell Dev Biol||[details]||22024020||-|
|A cytidine deaminase edits C to U in transfer RNAs in Archaea.||Randau L, Stanley BJ, Kohlway A, Mechta S, Xiong Y, Soll D||Science||[details]||19407206||-|
Last modification of this entry: 2012-07-03 16:56:32.514437
Edited by a user: magda
Edited content: Changed protein_sequence, if_enzyme, nomenclature, catalytic_domain_fold and comments.