"Profiling of RNA modifications by multiplexed stable isotope labelling."

Kellner S, Neumann J, Rosenkranz D, Lebedeva S, Ketting RF, Zischler H, Schneider D, Helm M.



Published 2014-04-04 in Chem Commun (Camb). volume 50(26):3516-8 .

Pubmed ID: 24567952
DOI identifier: 10.1039/c3cc49114e

Abstract:
The combination of (15)N/(13)C stable isotope labelling (SIL) and LC-MS/MS revealed a total of 52 modifications in RNA from E. coli and yeast, including 10 previously undescribed modifications. Two modifications, N-ribosylnicotinamide and 2-methylthioadenosine, were newly detected in species hitherto thought not to contain these modifications.


Entry added on: 2017-07-05 12:41:52.883995, by a user: pboccaletto