"Radical mediated ring formation in the biosynthesis of the hypermodified tRNA base wybutosine."

Young AP, Bandarian V...



Published 2013-08-01 in Curr Opin Chem Biol volume 17 .

Pubmed ID: 23856057
DOI identifier: -

Abstract:
Wyosine and its derivatives are highly modified, acid labile tricyclic bases found at position 37 of tRNA(Phe) in archaea and eukarya. The formation of the common 4-demethylwyosine structural feature entails condensation of pyruvate and N-methylguanosine catalyzed by TYW1. This review will focus on the mechanism of this complex radical mediated transformation.


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Last modification of this entry: May 20, 2014