"A METTL3-METTL14 complex mediates mammalian nuclear RNA N-adenosine methylation."

Liu J, Yue Y, Han D, Wang X, Fu Y, Zhang L, Jia G, Yu M, Lu Z, Deng X, Dai Q, Chen W, He C...



Published 2013-12-06 in Nat Chem Biol .

Pubmed ID: 24316715
DOI identifier: -

Abstract:
N6-methyladenosine (m6A) is the most prevalent and reversible internal modification in mammalian messenger and noncoding RNAs. We report here that human methyltransferase-like 14 (METTL14) catalyzes m6A RNA methylation. Together with METTL3, the only previously known m6A methyltransferase, these two proteins form a stable heterodimer core complex of METTL3-METTL14 that functions in cellular m6A deposition on mammalian nuclear RNAs. WTAP, a mammalian splicing factor, can interact with this complex and affect this methylation.


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Last modification of this entry: Dec. 20, 2013