"Expanding role of the jumonji C domain as an RNA hydroxylase."

Noma A, Ishitani R, Kato M, Nagao A, Nureki O, Suzuki T



Published 2010-11-05 in J Biol Chem volume 285 .

Pubmed ID: 20739293
DOI identifier: -

Abstract:
JmjC (Jumonji C) domain-containing proteins are known to be an extensive family of Fe(II)/2-oxoglutarate-dependent oxygenases involved in epigenetic regulation of gene expression by catalyzing oxidative demethylation of methylated histones. We report here that a human JmjC protein named Tyw5p (TYW5) unexpectedly acts in the biosynthesis of a hypermodified nucleoside, hydroxywybutosine, in tRNA(Phe) by catalyzing hydroxylation. The finding provides an insight into the expanding role of JmjC protein as an RNA hydroxylase.


This publication refers to following proteins:



Last modification of this entry: Sept. 6, 2012