"The methylthiolation reaction mediated by the Radical-SAM enzymes."

Atta M, Arragain S, Fontecave M, Mulliez E, Hunt JF, Luff JD, Forouhar F



Published 2011-12-07 in Biochim Biophys Acta .

Pubmed ID: 22178611
DOI identifier: -

Abstract:
Over the past 10years, considerable progress has been made in our understanding of the mechanistic enzymology of the Radical-SAM enzymes. It is now clear that these enzymes appear to be involved in a remarkably wide range of chemically challenging reactions. This review article highlights mechanistic and structural aspects of the methylthiotransferases (MTTases) sub-class of the Radical-SAM enzymes. The mechanism of methylthio insertion, now observed to be performed by three different enzymes is an exciting unsolved problem. This article is part of a Special Issue entitled: Radical SAM enzymes and Radical Enzymology.


This publication refers to following proteins:



Last modification of this entry: Sept. 6, 2012