"Antiviral amphipathic oligo- and polyribonucleotides: analogue development and biological studies."

Hyde RM, Broom AD, Buckheit RW Jr



Published 2003-05-08 in J Med Chem volume 46 .

Pubmed ID: 12723951
DOI identifier: -

Abstract:
A series of novel N1 alkylated purine nucleic acids were polymerized either enzymatically or by automated synthesis to further establish the SAR requirements for HIV, RT, and HCMV activity. Out of the series, two constructs, 2'-O-methyl-1-allylinosinic acid phosphorothioate 33-mer (16) and an oligomer incorporating 1-propyl-6-thioinosinic acid residues (20), were found to be highly active under all three assay conditions. SAR studies indicate that sulfur incorporation, high molecular weight, and low steric bulk at N1 all can be important for activity.


Entry added on: 2012-06-27 09:39:51.453255, by a user: mark