"A new RNA synthetic method with a 2'-O-(2-cyanoethoxymethyl) protecting group."

Ohgi T, Masutomi Y, Ishiyama K, Kitagawa H, Shiba Y, Yano J



Published 2005-08-04 in Org Lett volume 7 .

Pubmed ID: 16048321
DOI identifier: -

Abstract:
A novel method for the synthesis of RNA oligomers with 2-cyanoethoxymethyl (CEM) as the 2'-hydroxyl protecting group has been developed. The new method allows the synthesis of oligoribonucleotides with an efficiency and final purity comparable to that obtained in DNA synthesis. [structure: see text]


Entry added on: 2012-06-27 09:15:56.255461, by a user: mark