"Ein neuer Zugang zu 2’-O-Alkylribonucleosiden und Eigenschaften deren Oligonucleotide"

Pierre Martin



Published 1994-12-30 in Helvetica Chimica Acta volume Volume 78, Issue 2 .

Pubmed ID: -
DOI identifier: 10.1002/hlca.19950780219

Abstract:
A general access to 2’-0-alkylated ribonucleosides using the key intermediate 5 is presented. The incorporationof 2’-O-‘ethyleneglycol’- and 2‘-0-‘glycerol’-substituted (ie., 2’-0-(2-hydroxyethyl)- and 2’4 -(2,3-dihydroxypropy1)-substituted) ribonucleosides into oligonucleotides affords a new generation of oligonucleotides with high affinity for RNA, high specificity, and increased nuclease resistance.


Entry added on: 2012-06-27 08:56:10.471151, by a user: mark