"S-Adenosylmethionine-dependent radical-based modification of biological macromolecules."

Atta M, Mulliez E, Arragain S, Forouhar F, Hunt JF, Fontecave M



Published 2010-12-01 in Curr Opin Struct Biol volume 20 .

Pubmed ID: 20951571
DOI identifier: -

Abstract:
Proteins and RNA molecules enjoy a variety of chemically complex post-translational and post-transcriptional modifications. The chemistry at work in these reactions, which was considered to be exclusively ionic in nature has recently been shown to depend on radical mechanisms in some cases. The overwhelming majority of these radical-based reactions are catalyzed by 'Radical-SAM' enzymes. This review article highlights mechanistic and structural aspects of this class of reactions and indicates important research directions to be addressed.


This publication refers to following proteins:



Last modification of this entry: Sept. 6, 2012