"The yggH gene of Escherichia coli encodes a tRNA (m7G46) methyltransferase."

De Bie LG, Roovers M, Oudjama Y, Wattiez R, Tricot C, Stalon V, Droogmans L, Bujnicki JM

Published 2003-05-01 in J Bacteriol volume 185 .

Pubmed ID: 12730187
DOI identifier: -

We cloned, expressed, and purified the Escherichia coli YggH protein and show that it catalyzes the S-adenosyl-L-methionine-dependent formation of N(7)-methylguanosine at position 46 (m(7)G46) in tRNA. Additionally, we generated an E. coli strain with a disrupted yggH gene and show that the mutant strain lacks tRNA (m(7)G46) methyltransferase activity.

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Last modification of this entry: Sept. 6, 2012