"Synthesis and Incorporation of 2′-O-Methyl-Pseudouridine into Oligonucleotides"
Bruce S. Rossa, Guillermo Vasqueza, Sheri Manalilia, Elena Lesnika, Richard Griffeya
Published 1997-01-01 in Nucleosides and Nucleotides volume Volume 16, Issue 7-9 .
Pubmed ID: -
DOI identifier: 10.1080/07328319708006226
|A short multigram synthesis of 2′-O-methylpseudouridine and its phosphoramidite derivative is described which avoids the use of protecting groups on the nitrogens. A binding study of oligonucleotides containing this modification suggest an increased binding affinity to RNA when compared to oligonucleotides incorporating 2′-O-methyluridine.|
Last modification of this entry: 2012-05-31 10:04:53.198994
Edited by a user: mark
Edited content: Changed first_author.