"Direct evidence for enzyme persulfide and disulfide intermediates during 4-thiouridine biosynthesis."

Wright CM, Christman GD, Snellinger AM, Johnston MV, Mueller EG



Published 2006-08-07 in Chem Commun (Camb) volume 29 .

Pubmed ID: 16855700
DOI identifier: -

Abstract:
Two proposed mechanisms for 4-thiouridine generation share key cysteine persulfide and disulfide intermediates, and indirect evidence of their existence has been previously reported; chemical trapping and mass spectrometry have now provided direct and definitive evidence of these key intermediates.


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Entry added on: 2012-02-02 16:10:20.848390, by a user: magda