"THUMP--a predicted RNA-binding domain shared by 4-thiouridine, pseudouridine synthases and RNA methylases."

Aravind L, Koonin EV

Published 2001-04-01 in Trends Biochem Sci volume 26 .

Pubmed ID: 11295541
DOI identifier: -

Sequence profile searches were used to identify an ancient domain in ThiI-like thiouridine synthases, conserved RNA methylases, archaeal pseudouridine synthases and several uncharacterized proteins. We predict that this domain is an RNA-binding domain that adopts an alpha/beta fold similar to that found in the C-terminal domain of translation initiation factor 3 and ribosomal protein S8.

Last modification of this entry: Sept. 6, 2012