"Human mitochondrial transcription factor B1 methylates ribosomal RNA at a conserved stem-loop."

Seidel-Rogol BL, McCulloch V, Shadel GS



Published 2003-02-01 in Nat Genet volume 33 .

Pubmed ID: 12496758
DOI identifier: -

Abstract:
Human mitochondrial transcription factor B1 (h-mtTFB1) has an unprecedented relationship to RNA methyltransferases. Here, we show that this protein methylates a conserved stem-loop in bacterial 16S rRNA and that the homologous sequence in the human mitochondrial 12S molecule is similarly modified. Thus, h-mtTFB1 appears to be dual-function protein, acting both as a transcription factor and an rRNA-modification enzyme.


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Last modification of this entry: Sept. 6, 2012