Modification Summary


[show modification pathway]


Full name2-thiocytidine
Short names2C
New Nomenclature2C
RNAMods abbreviation%
HTML abbreviation%
Enzymes TtcA (Escherichia coli)
Found in phylogenyEubacteria
Found in RNAtRNA
PubChem ID3011746
SMILES codeC3(OC(CO)C(O)C(O)3)N1C=CC(N)=NC1(=S)

LC-MS Information

Sum formulaC9O4N3H13S1
Monoisotopic mass259.062676
Average mass259.284795
HRMS mass259.062128
Normalized LC elution time
LC elution order/characteristics
LC literature references
MS Data File
MS/MS Data File
MS/MS/MS (base ion) Data File
MS literature references

Download [.mol file for s2C]


s2C at position 32 in bacterial tRNA allows more anticodon loop flexibility that limit formation of the characteristic U33-turn conformation of anticodon loop in other tRNA lacking s2C32.

Chemical groups contained

heavy atomsulfur

Reactions producing 2-thiocytidine



Title Authors Journal Details PubMed Id DOI
Thiobases in Escherchia coli Transfer RNA: 2-Thiocytosine and 5-Methylaminomethyl-2-thiouracil. Carbon J, David H, Studier MH Science [details] 17812290 -
Modifications Modulate Anticodon Loop Dynamics and Codon Recognition of E. coli tRNA(Arg1,2). Cantara WA, Bilbille Y, Kim J, Kaiser R, LeszczyƄska G, Malkiewicz A, Agris PF J Mol Biol [details] 22240457 -

Last modification of this entry: 2013-05-10 16:36:52.755130
Edited by a user: magda
Edited content: Kingdom/s added to a modification