Modification Summary

5-methylaminomethyl-2-geranylthiouridine

[show modification pathway]
mnm5ges2U

Summary

Full name5-methylaminomethyl-2-geranylthiouridine
Short namemnm5ges2U
New Nomenclature21511U
RNAMods abbreviationh
HTML abbreviationh
Enzymes MnmH (Escherichia coli)
Found in phylogenyEubacteria
Found in RNAtRNA
SMILES codeC/C(C)=C\CCC(\C)=C\CSC1=NC(=O)C(CNC)=CN1[C@@H]2O[C@H](CO)[C@H](O)C2O

LC-MS Information

Sum formulaC21H33N3O5S
Monoisotopic mass439.2141
Average mass439.5762
[M+H]+440.2219
Product ions308
Normalized LC elution time * not available
LC elution order/characteristics not available

* normalized to guanosine (G), measured with a RP C-18 column with acetonitrile/ammonium acetate as mobile phase.

Download [.mol file for mnm5ges2U]

Comments

Present in position 34 in about 2.8-6.7% of E. coli tRNALysUUU and tRNAGluUUC.

Chemical groups contained

aminoalkylaminomethyl
hydrocarbonmethyl
sulphurthio
hydrocarbongeranyl

Reactions producing 5-methylaminomethyl-2-geranylthiouridine

Name
mnm5s2U:mnm5ges2U
nm5ges2U:mnm5ges2U

Publications

Title Authors Journal Details PubMed Id DOI
A gain of function mutation in a protein mediates production of novel modified nucleosides. Chen P, Crain PF, Nasvall SJ, Pomerantz SC, Bjork GR... EMBO J [details] 15861125 -
Discovery and biological characterization of geranylated RNA in bacteria. Dumelin CE, Chen Y, Leconte AM, Chen YG, Liu DR... Nat Chem Biol [details] 22983156 -

Last modification of this entry: 2014-04-01 17:51:43.701642
Edited by a user: magda
Edited content: RNA type/s added to a modification