Modification Summary

7-methylguanosine cap (cap 0)

[show modification pathway]


Full name7-methylguanosine cap (cap 0)
Short namem7Gpp(pN)
New Nomenclature79553N
RNAMods abbreviation©
HTML abbreviation©
Enzymes Abd1 (Saccharomyces cerevisiae)
Hcm1 (Homo sapiens)
Found in phylogenyEukaryota
Found in RNAmRNA, snRNA
SMILES code[O-]P([O-])(=O)OP([O-])(=O)OC[C@@H]3O[C@H](n2c[n+](C)c1c2N=C(N)NC1=O)C(O)[C@@H]3O

LC-MS Information

Sum formulaC11H15N5O11P2
Monoisotopic mass455.0243
Average mass455.2147
[M+H]+ not available
Product ions not available
Normalized LC elution time * not available
LC elution order/characteristics not available

* normalized to guanosine (G), measured with a RP C-18 column with acetonitrile/ammonium acetate as mobile phase.

Download [.mol file for m7Gpp(pN)]


wikipedia: The 5' cap is found on the 5' end of an mRNA molecule and consists of a guanine nucleotide connected to the mRNA via an unusual 5' to 5' triphosphate linkage. This guanosine is methylated on the 7 position directly after capping in vitro by a methyl transferase. It is referred to as a 7-methylguanosine cap, abbreviated m7G. Most properties, save the triphosphate linkage, are the same as any other 7-methylguanosine.

Chemical groups contained

methyl groupmethyl group

Reactions producing 7-methylguanosine cap (cap 0)


Reactions starting from 7-methylguanosine cap (cap 0)


Last modification of this entry: 2014-07-11 14:57:56.011938
Edited by a user: magda
Edited content: Changed formula, formula_html, smile, esc_smile, mass_monoiso, mass_avg and mass_hrms.