Modification Summary


[show modification pathway]


Full nameN6-methyl-N6-threonylcarbamoyladenosine
Short namem6t6A
New Nomenclature662A
RNAMods abbreviationE
HTML abbreviationE
Enzymes TRMO (Homo sapiens)
TrmO (Escherichia coli)
Found in phylogenyEubacteria
Found in RNAtRNA
SMILES codeO=C(O)C(NC(=O)N(C)c3ncnc2c3ncn2[C@@H]1O[C@H](CO)[C@H](O)C1O)C(C)O

LC-MS Information

Sum formulaC16O8N6H22
Monoisotopic mass426.149911
Average mass426.386836
HRMS mass426.149362
Normalized LC elution time *1,93 (Kellner 2014)
LC elution order/characteristicsbetween A and m6A (Kellner 2014)
Mass transition-132 (Kellner 2014)

* normalized to guanosine (G), measured with a RP C-18 column with acetonitrile/ammonium acetate as mobile phase.

LC-MS Publications

Title Authors Journal Details PubMed Id DOI
Profiling of RNA modifications by multiplexed stable isotope labelling. Kellner S, Neumann J, Rosenkranz D, Lebedeva S, Ketting RF, Zischler H, Schneider D, Helm M. Chem Commun (Camb). [details] 24567952 -

Download [.mol file for m6t6A]

Chemical groups contained

aminoacyl groupthreonyl
methyl groupmethyl at other N

Reactions producing N6-methyl-N6-threonylcarbamoyladenosine


Occurrence in PDB structures

PDB-ID chain residue
1qf6 B AET /37

Last modification of this entry: 2017-07-05 16:47:50.257730
Edited by a user: pboccaletto
Edited content: Changed lc_elution_time, lc_elution_comment, lc_reference and mass_trans.