Modification Summary


[show modification pathway]


Full name1-methylguanosine
Short namem1G
New Nomenclature1G
RNAMods abbreviationK
HTML abbreviationK
Enzymes AviRa (Streptomyces viridochromogenes)
RlmA(I) (Escherichia coli)
RlmA(II) (Streptomyces fradiae)
TRM5 (Homo sapiens)
TRMT10A (Homo sapiens)
TRMT10B (Homo sapiens)
TRMT10C (Homo sapiens)
Taw22 (Pyrococcus abyssi)
Trm10 (Saccharomyces cerevisiae)
Trm5 (Saccharomyces cerevisiae)
Trm5b (Methanocaldococcus jannaschii)
Trm5b (Pyrococcus abyssi)
TrmD (Escherichia coli)
Found in phylogenyArchaea, Eubacteria, Eukaryota
Found in RNArRNA, tRNA
PubChem ID96373
SMILES codeC3(OC(CO)C(O)C(O)3)N2C=NC1=C2N=C(N)N(C)C1=O

LC-MS Informations

Sum formulaC11O5N5H15
Monoisotopic mass297.107318
Average mass297.271183
HRMS mass297.106769
Normalized LC elution time *1,23 (Kellner 2014); 1,28 (Kellner 2014)
LC elution order/characteristicsbetween G and A (Kellner 2014, Kellner 2014)
Mass transition-132 (Kellner 2014, Kellner 2014, Su 2014)

* normalized to guanosine (G), measured with a RP C-18 column with acetonitrile/ammonium acetate as mobile phase.

LC-MS Publications

Title Authors Journal Details PubMed Id DOI
Profiling of RNA modifications by multiplexed stable isotope labelling. Kellner S, Neumann J, Rosenkranz D, Lebedeva S, Ketting RF, Zischler H, Schneider D, Helm M. Chem Commun (Camb). [details] 24567952 -
Quantitative analysis of ribonucleoside modifications in tRNA by HPLC-coupled mass spectrometry. Su D, Chan CT, Gu C, Lim KS, Chionh YH, McBee ME, Russell BS, Babu IR, Begley TJ, Dedon PC... Nat Protoc [details] 24625781 -
Absolute and relative quantification of RNA modifications via biosynthetic isotopomers. Kellner S, Ochel A, Thuring K, Spenkuch F, Neumann J, Sharma S, Entian KD, Schneider D, Helm M... Nucleic Acids Res [details] 25129236 -

Download [.mol file for m1G]

Chemical groups contained

methyl groupmethyl at aromatic N

Reactions producing 1-methylguanosine


Reactions starting from 1-methylguanosine


Occurrence in PDB structures

PDB-ID chain residue
1asy R 1MG /637
1asy S 1MG /637
1asz R 1MG /637
1asz S 1MG /637
1f7u B 1MG /909
1f7v B 1MG /909
1il2 C 1MG /937
1il2 D 1MG /1937
1luu A 1MG /37
1yfg 1MG /9
2tra 1MG /37
3tra 1MG /37
486d C 1MG /37
486d E 1MG /37

Last modification of this entry: 2017-07-05 16:10:22.849924
Edited by a user: pboccaletto
Edited content: Changed lc_elution_time, lc_elution_comment, lc_reference and mass_trans.