Modification Summary

1-methyladenosine

[show modification pathway]
m1A

Summary

Full name1-methyladenosine
Short namem1A
New Nomenclature1A
RNAMods abbreviation"
HTML abbreviation"
Enzymes Bmt2 (Saccharomyces cerevisiae)
KamB (Streptomyces sp. DSM 40477)
NpmA (Escherichia coli)
Rrp8 (Saccharomyces cerevisiae)
TRMT10C (Homo sapiens)
Trm61 (Saccharomyces cerevisiae)
TrmI (Pyrococcus abyssi)
TrmI (Thermus thermophilus)
TrmI (Mycobacterium tuberculosis)
TrmK (Bacillus subtilis)
Trmt61A (Homo sapiens)
Trmt61B (Homo sapiens)
Found in phylogenyArchaea, Eubacteria, Eukaryota
Found in RNArRNA, tRNA
PubChem ID27476
SMILES codeC3(OC(CO)C(O)C(O)3)N2C=NC1=C2N=CN(C)C1=N

LC-MS Information

Sum formulaC11O4N5H15
Monoisotopic mass281.112403
Average mass281.271879
HRMS mass281.111855
Normalized LC elution time *0,64 (Kellner 2014); 0,72 (Kellner 2014)
LC elution order/characteristicsbetween U and G (Kellner 2014, Kellner 2014)
Mass transition-132 (Kellner 2014, Kellner 2014, Su 2014)

* normalized to guanosine (G), measured with a RP C-18 column with acetonitrile/ammonium acetate as mobile phase.

LC-MS Publications

Title Authors Journal Details PubMed Id DOI
Profiling of RNA modifications by multiplexed stable isotope labelling. Kellner S, Neumann J, Rosenkranz D, Lebedeva S, Ketting RF, Zischler H, Schneider D, Helm M. Chem Commun (Camb). [details] 24567952 -
Quantitative analysis of ribonucleoside modifications in tRNA by HPLC-coupled mass spectrometry. Su D, Chan CT, Gu C, Lim KS, Chionh YH, McBee ME, Russell BS, Babu IR, Begley TJ, Dedon PC... Nat Protoc [details] 24625781 -
Absolute and relative quantification of RNA modifications via biosynthetic isotopomers. Kellner S, Ochel A, Thuring K, Spenkuch F, Neumann J, Sharma S, Entian KD, Schneider D, Helm M... Nucleic Acids Res [details] 25129236 -

Download [.mol file for m1A]

Comments

m1A has a positive charge at neutral pH.

Chemical groups contained

methyl groupmethyl at aromatic N

Reactions producing 1-methyladenosine

Name
A:m1A

Reactions starting from 1-methyladenosine

Name
m1A:m1I
m1A:m1Am

Occurrence in PDB structures

PDB-ID chain residue
1c2w B 1MA /1618
1c2w B 1MA /2030
1ehz A 1MA /58
1evv A 1MA /58
1f7u B 1MA /958
1f7v B 1MA /958
1fcw A 1MA /58
1fcw B 1MA /58
1fcw C 1MA /58
1fcw D 1MA /58
1fcw E 1MA /58
1fir A 1MA /58
1gix B 1MA /58
1gix C 1MA /58
1h3e B MAD /58
1jgo B 1MA /58
1jgo C 1MA /58
1jgp B 1MA /58
1jgp C 1MA /58
1jgq B 1MA /58
1jgq C 1MA /58
1mj1 D 1MA /58
1mj1 C 1MA /58
1ml5 B 1MA /58
1ob2 B MAD /58
1ob5 B MAD /58
1ob5 D MAD /58
1ob5 F MAD /58
1s72 0 1MA /628
1sz1 E 1MA /58
1sz1 F 1MA /58
1tn2 1MA /58
1tra 1MA /58
1ttt D 1MA /58
1ttt E 1MA /58
1ttt F 1MA /58
1vq4 0 1MA /628
1vq5 0 1MA /628
1vq6 0 1MA /628
1vq7 0 1MA /628
1vq8 0 1MA /628
1vq9 0 1MA /628
1vqk 0 1MA /628
1vql 0 1MA /628
1vqm 0 1MA /628
1vqn 0 1MA /628
1vqo 0 1MA /628
1vqp 0 1MA /628
1yfg 1MA /58
1yhq 0 1MA /628
1yi2 0 1MA /628
1yij 0 1MA /628
1yit 0 1MA /628
1yj9 0 1MA /628
1yjn 0 1MA /628
1yjw 0 1MA /628
486d C 1MA /58
4tna 1MA /58
4tra 1MA /58
6tna 1MA /58

Last modification of this entry: 2017-07-05 15:33:19.084870
Edited by a user: pboccaletto
Edited content: Changed lc_elution_time, lc_elution_comment, lc_reference and mass_trans.