Modification Summary
5-hydroxyuridine
[show modification pathway]
Summary
| Full name | 5-hydroxyuridine |
| Short name | ho5U |
| New Nomenclature | 50U |
| RNAMods abbreviation | ∝ |
| HTML abbreviation | ∝ |
| Enzymes |
|
| Found in phylogeny | Eubacteria |
| Found in RNA | |
| SMILES code | C3(OC(CO)C(O)C(O)3)N1C=C(O)C(=O)NC1(=O) |
LC-MS Information
| Sum formula | C9O7N2H12 |
| Monoisotopic mass | 260.06445 |
| Average mass | 260.203622 |
| HRMS mass | 260.063902 |
| Normalized LC elution time * | not available |
| LC elution order/characteristics | not available |
| Mass transition | not available |
* normalized to guanosine (G), measured with a RP C-18 column with acetonitrile/ammonium acetate as mobile phase.
Comments
ho5U at the wobble position of bacterial tRNA has been demonstrated in null-mutation CmoB. Null mutation of CmoA in S. enterica results in the accummulation of tRNA containing mo5U34 and ho5U34.
Chemical groups contained
Reactions producing 5-hydroxyuridine
Reactions starting from 5-hydroxyuridine
Publications
| Title |
Authors |
Journal |
Details |
PubMed Id |
DOI |
| Isolation of 5-hydroxyuridine (iso-barbituridine) from yeast ribonucleic acids. |
Lis AW, Passarge WE |
Arch Biochem Biophys |
[details]
|
5957714
|
-
|
| The wobble hypothesis revisited: uridine-5-oxyacetic acid is critical for reading of G-ending codons. |
Nasvall SJ, Chen P, Bjork GR |
RNA |
[details]
|
17942742
|
-
|
Last modification of this entry: 2013-05-10 16:36:58.555487
Edited by a user: magda
Edited content: Kingdom/s added to a modification
