Modification Summary

uridine 5-oxyacetic acid

[show modification pathway]
cmo5U

Summary

Full nameuridine 5-oxyacetic acid
Short namecmo5U
New Nomenclature502U
RNAMods abbreviationV
HTML abbreviationV
Enzymes CmoB (Escherichia coli)
Found in phylogenyEubacteria
Found in RNAtRNA
PubChem ID193091
SMILES codeC3(OC(CO)C(O)C(O)3)N1C=C(OCC(=O)O)C(=O)NC1(=O)

LC-MS Information

Sum formulaC11O9N2H14
Monoisotopic mass318.069929
Average mass318.240257
HRMS mass318.069381
Normalized LC elution time
LC elution order/characteristics
LC literature references
MS Data File
MS/MS Data File
MS/MS/MS (base ion) Data File
MS literature references

Download [.mol file for cmo5U]

Comments

Earlier called the V nucleoside. Base pairs with A, G and U in mRNA. cmo5U (and mcmo5U) is a modification characteristic for gram negative bacteria (E. coli, Protebacteria). Gram positive bacteria (B. subtilis, Firmicutes) have mo5U in this position.

Chemical groups contained

othercarboxymethyl
othermethoxy

Reactions producing uridine 5-oxyacetic acid

Name
ho5U:cmo5U
mo5U:cmo5U

Reactions starting from uridine 5-oxyacetic acid

Name
cmo5U:mcmo5U

Publications

Title Authors Journal Details PubMed Id DOI
Uridin-5-oxy acetic acid: a new minor constituent from E. coli valine transfer RNA I. Murao K, Saneyoshi M, Harada F, Nishimura S Biochem Biophys Res Commun [details] 4910247 -
The wobble hypothesis revisited: uridine-5-oxyacetic acid is critical for reading of G-ending codons. Nasvall SJ, Chen P, Bjork GR RNA [details] 17942742 -

Last modification of this entry: 2013-05-10 16:37:11.302650
Edited by a user: magda
Edited content: Kingdom/s added to a modification