Modification Summary

2′-O-methylguanosine

[show modification pathway]
Gm

Summary

Full name2′-O-methylguanosine
Short nameGm
New Nomenclature0G
RNAMods abbreviation#
HTML abbreviation#
Enzymes MRM1 (Homo sapiens)
Mrm1 (Saccharomyces cerevisiae)
Nop1 (Saccharomyces cerevisiae)
RNMTL1 (Homo sapiens)
RlmB (Escherichia coli)
Spb1 (Saccharomyces cerevisiae)
Trm3 (Saccharomyces cerevisiae)
Trm7 (Saccharomyces cerevisiae)
TrmH (Escherichia coli)
TrmH (Thermus thermophilus)
Found in phylogenyEubacteria, Eukaryota
Found in RNArRNA, snRNA, tRNA
PubChem ID188959
SMILES codeC3(OC(CO)C(O)C(O(C))3)N2C=NC1=C2N=C(N)NC1=O

LC-MS Information

Sum formulaC11O5N5H15
Monoisotopic mass297.1073
Average mass297.2712
[M+H]+298.1144
Product ions152
Normalized LC elution time *1,23 (Kellner 2014); 1,28 (Kellner 2014)
LC elution order/characteristicsbetween G and A (Kellner 2014, Kellner 2014)

* normalized to guanosine (G), measured with a RP C-18 column with acetonitrile/ammonium acetate as mobile phase.

LC-MS Publications

Title Authors Journal Details PubMed Id DOI
Profiling of RNA modifications by multiplexed stable isotope labelling. Kellner S, Neumann J, Rosenkranz D, Lebedeva S, Ketting RF, Zischler H, Schneider D, Helm M. Chem Commun (Camb). [details] 24567952 -
Quantitative analysis of ribonucleoside modifications in tRNA by HPLC-coupled mass spectrometry. Su D, Chan CT, Gu C, Lim KS, Chionh YH, McBee ME, Russell BS, Babu IR, Begley TJ, Dedon PC... Nat Protoc [details] 24625781 -
Absolute and relative quantification of RNA modifications via biosynthetic isotopomers. Kellner S, Ochel A, Thuring K, Spenkuch F, Neumann J, Sharma S, Entian KD, Schneider D, Helm M... Nucleic Acids Res [details] 25129236 -

Download [.mol file for Gm]

Chemical groups contained

methyl groupmethyl at O2

Reactions producing 2′-O-methylguanosine

Name
G:Gm

Reactions starting from 2′-O-methylguanosine

Name
Gm:m2Gm
Gm:m1Gm

Occurrence in PDB structures

PDB-ID chain residue
1ehz A OMG /34
1evv A OMG /34
1fcw A OMG /34
1fcw B OMG /34
1fcw C OMG /34
1fcw D OMG /34
1fcw E OMG /34
1gix B OMG /34
1gix C OMG /34
1jgo B OMG /34
1jgo C OMG /34
1jgp B OMG /34
1jgp C OMG /34
1jgq B OMG /34
1jgq C OMG /34
1luu A OMG /34
1lux A OMG /34
1mj1 D OMG /34
1mj1 C OMG /34
1ml5 B OMG /34
1nao B OMG /10
1ob2 B OMG /34
1ob5 B OMG /34
1ob5 D OMG /34
1ob5 F OMG /34
1pbl A OMG /2
1pbl A OMG /4
1pbl A OMG /6
1pbl B OMG /8
1pbl B OMG /10
1s72 0 OMG /2588
1sz1 E OMG /34
1sz1 F OMG /34
1tn2 OMG /34
1tra OMG /34
1ttt D OMG /34
1ttt E OMG /34
1ttt F OMG /34
1vq4 0 OMG /2588
1vq5 0 OMG /2588
1vq6 0 OMG /2588
1vq7 0 OMG /2588
1vq8 0 OMG /2588
1vq9 0 OMG /2588
1vqk 0 OMG /2588
1vql 0 OMG /2588
1vqm 0 OMG /2588
1vqn 0 OMG /2588
1vqo 0 OMG /2588
1vqp 0 OMG /2588
1yhq 0 OMG /2588
1yi2 0 OMG /2588
1yij 0 OMG /2588
1yit 0 OMG /2588
1yj9 0 OMG /2588
1yjn 0 OMG /2588
1yjw 0 OMG /2588
4tna OMG /34
4tra OMG /34
6tna OMG /34

Last modification of this entry: 2017-10-06 19:51:53.570384
Edited by a user: pboccaletto
Edited content: Changed product_ions.