Modified bases


Showing all 170 modifications.
New Nomenclature Name Short Name RNAMods abbrev. HTML abbrev. Formula Monoisotopic mass Average mass
01A 1,2′-O-dimethyladenosine m1Am œ œ C12O4N5H17 295.1281 295.2989
01G 1,2′-O-dimethylguanosine m1Gm ε ε C12O5N5H17 311.123 311.2977
019A 1,2′-O-dimethylinosine m1Im ξ ξ C12O5N4H16 296.1121 296.2835
1309U 1-methyl-3-(3-amino-3-carboxypropyl)pseudouridine m1acp3Y α α C14O8N3H21 359.1329 359.3366
1A 1-methyladenosine m1A " " C11O4N5H15 281.1124 281.2719
1G 1-methylguanosine m1G K K C11O5N5H15 297.1073 297.2712
19A 1-methylinosine m1I O O C11O5N4H14 282.0964 282.2565
19U 1-methylpseudouridine m1Y ] ] C10O6N2H14 258.0852 258.2313
28A 2,8-dimethyladenosine m2,8A ± ± C12H17N5O4 295.1281 295.2983
21U 2-geranylthiouridine ges2U Γ Γ C19H28N2O5S 396.1719 396.5078
21C 2-lysidine k2C } } C15O6N5H25 371.1805 371.3944
2A 2-methyladenosine m2A / / C11O4N5H15 281.1124 281.2719
2164A 2-methylthio cyclic N6-threonylcarbamoyladenosine ms2ct6A ÿ ÿ C17H21N5O7S 439.1162 439.4429
2160A 2-methylthio-N6-(cis-hydroxyisopentenyl) adenosine ms2io6A C16O5N5H23S1 397.142 397.4546
2163A 2-methylthio-N6-hydroxynorvalylcarbamoyladenosine ms2hn6A C17O8N6H24S1 472.1376 472.4782
2161A 2-methylthio-N6-isopentenyladenosine ms2i6A * * C16O4N5H23S1 381.1471 381.4553
621A 2-methylthio-N6-methyladenosine ms2m6A C12O4N5H17S1 327.1001 327.3633
2162A 2-methylthio-N6-threonylcarbamoyladenosine ms2t6A [ [ C16O8N6H22S1 458.122 458.4512
20U 2-selenouridine se2U ω ω C9O5N2H12Se1 305.9919 306.1221
02U 2-thio-2′-O-methyluridine s2Um C10O5N2H14S1 274.0623 274.2964
2C 2-thiocytidine s2C % % C9O4N3H13S1 259.0627 259.2848
2U 2-thiouridine s2U 2 2 C9O5N2H12S1 260.0467 260.2694
0A 2′-O-methyladenosine Am : : C11O4N5H15 281.1124 281.2719
0C 2′-O-methylcytidine Cm B B C10O5N3H15 257.1012 257.2467
0G 2′-O-methylguanosine Gm # # C11O5N5H15 297.1073 297.2712
09A 2′-O-methylinosine Im C11O5N4H14 282.0964 282.2565
09U 2′-O-methylpseudouridine Ym Z Z C10O6N2H14 258.0852 258.2313
0U 2′-O-methyluridine Um J J C10O6N2H14 258.0852 258.2313
0503U 2′-O-methyluridine 5-oxyacetic acid methyl ester mcmo5Um Ͽ Ͽ C13H18N2O9 346.292 346.1012
00A 2′-O-ribosyladenosine (phosphate) Ar(p) ^ ˆ C15O11N5H22P1 479.1053 479.3408
00G 2′-O-ribosylguanosine (phosphate) Gr(p) C15O12N5H22P1 495.1003 495.3401
3377N 2′3′-cyclic phosphate end (pN)2′3′>p None None
03U 3,2′-O-dimethyluridine m3Um σ σ C11O6N2H16 272.1008 272.2583
308U 3-(3-amino-3-carboxypropyl)-5,6-dihydrouridine acp3D Ð Ð C13H21N3O8 347.1329 347.3252
309U 3-(3-amino-3-carboxypropyl)pseudouridine acp3Y Þ Þ C13H19N3O8 345.1172 345.3093
30U 3-(3-amino-3-carboxypropyl)uridine acp3U X X C13O8N3H19 345.1172 345.3096
3C 3-methylcytidine m3C ' ' C10O5N3H15 257.1012 257.2467
39U 3-methylpseudouridine m3Y κ κ C10O6N2H14 258.0852 258.2313
3U 3-methyluridine m3U δ δ C10O6N2H14 258.0852 258.2313
4G 4-demethylwyosine imG-14 C13O5N5H15 321.1073 321.2933
74U 4-thiouridine s4U 4 4 C9O5N2H12S1 260.0467 260.2694
05C 5,2′-O-dimethylcytidine m5Cm τ τ C11O5N3H17 271.1168 271.2737
05U 5,2′-O-dimethyluridine m5Um \ \ C11O6N2H16 272.1008 272.2583
0522U 5-(carboxyhydroxymethyl)-2′-O-methyluridine methyl ester mchm5Um b b C13H18N2O9 346.1012 346.294
522U 5-(carboxyhydroxymethyl)uridine methyl ester mchm5U , , C12O9N2H16 332.0856 332.2672
2583U 5-(isopentenylaminomethyl)-2-thiouridine inm5s2U ½ ½ C15H23N3O5S 357.1358 357.4308
0583U 5-(isopentenylaminomethyl)-2′-O-methyluridine inm5Um ¼ ¼ C16H25N3O6 355.1743 355.3911
583U 5-(isopentenylaminomethyl)uridine inm5U ¾ ¾ C15H23N3O6 341.1587 341.3642
21510U 5-aminomethyl-2-geranylthiouridine nm5ges2U Δ Δ C20H31N3O5S 425.1984 425.5494
20510U 5-aminomethyl-2-selenouridine nm5se2U π π C10O5N3H15Se1 337.0176 336.2032
2510U 5-aminomethyl-2-thiouridine nm5s2U C10O5N3H15S1 289.0732 289.3111
510U 5-aminomethyluridine nm5U C10O6N3H15 273.0961 273.246
531U 5-carbamoylhydroxymethyluridine nchm5U r r C11H15N3O8 317.0859 317.2555
253U 5-carbamoylmethyl-2-thiouridine ncm5s2U l l C11H15N3O6S 317.0681 317.3227
053U 5-carbamoylmethyl-2′-O-methyluridine ncm5Um ~ C12O7N3H17 315.1066 315.2833
53U 5-carbamoylmethyluridine ncm5U & & C11O7N3H15 301.091 301.2563
520U 5-carboxyhydroxymethyluridine chm5U C11O9N2H14 318.0699 318.2403
2540U 5-carboxymethyl-2-thiouridine cm5s2U C11O7N2H14S1 318.0522 318.306
2151U 5-carboxymethylaminomethyl-2-geranylthiouridine cmnm5ges2U f f C22H33N3O7S 483.2039 483.586
2051U 5-carboxymethylaminomethyl-2-selenouridine cmnm5se2U C12O7N3H17Se1 393.0239 393.2003
251U 5-carboxymethylaminomethyl-2-thiouridine cmnm5s2U $ $ C12O7N3H17S1 347.0787 347.3477
051U 5-carboxymethylaminomethyl-2′-O-methyluridine cmnm5Um ) ) C13O8N3H19 345.1172 345.3096
51U 5-carboxymethylaminomethyluridine cmnm5U ! ! C12O8N3H17 331.1016 331.2826
52U 5-carboxymethyluridine cm5U C11O8N2H14 302.075 302.241
55U 5-cyanomethyluridine cnm5U Ѷ Ѷ C11H13N3O6 283.0804 283.2408
071C 5-formyl-2′-O-methylcytidine f5Cm ° ° C11O6N3H15 285.0961 285.257
71C 5-formylcytidine f5C > > C10O6N3H13 271.0804 271.2301
50C 5-hydroxycytidine ho5C Ç Ç C9H13N3O6 259.0804 259.2188
51C 5-hydroxymethylcytidine hm5C C10O6N3H15 273.0961 273.246
50U 5-hydroxyuridine ho5U C9O7N2H12 260.0645 260.2036
2521U 5-methoxycarbonylmethyl-2-thiouridine mcm5s2U 3 3 C12O7N2H16S1 332.0678 332.333
0521U 5-methoxycarbonylmethyl-2′-O-methyluridine mcm5Um C13O8N2H18 330.1063 330.2949
521U 5-methoxycarbonylmethyluridine mcm5U 1 1 C12O8N2H16 316.0907 316.2679
501U 5-methoxyuridine mo5U 5 5 C10O7N2H14 274.0801 274.2306
25U 5-methyl-2-thiouridine m5s2U F F C10O5N2H14S1 274.0623 274.2964
21511U 5-methylaminomethyl-2-geranylthiouridine mnm5ges2U h h C21H33N3O5S 439.2141 439.5762
20511U 5-methylaminomethyl-2-selenouridine mnm5se2U C11O5N3H17Se1 349.0341 349.1905
2511U 5-methylaminomethyl-2-thiouridine mnm5s2U S S C11O5N3H17S1 303.0889 303.3381
511U 5-methylaminomethyluridine mnm5U { { C11O6N3H17 287.1117 287.273
5C 5-methylcytidine m5C ? ? C10O5N3H15 257.1012 257.2467
58U 5-methyldihydrouridine m5D ρ ρ C10O6N2H16 260.1008 260.2473
5U 5-methyluridine m5U T T C10O6N2H14 258.0852 258.2313
254U 5-taurinomethyl-2-thiouridine tm5s2U C12O8N3H19S2 397.0614 397.4274
54U 5-taurinomethyluridine tm5U Ê Ê C12O9N3H19S1 381.0842 381.3623
455N 5′ (3′ -dephospho-CoA) CoA(pN) C21H32N7O13P2S 684.1254 684.538
4155N 5′ (3′ -dephosphoacetyl-CoA) acCoA(pN) C22H40N7O15P2S 736.1778 736.6113
4255N 5′ (3′ -dephosphomalonyl-CoA) malonyl-CoA(pN) C23H40N7O17P2S 780.1676 780.6211
4355N 5′ (3′ -dephosphosuccinyl-CoA) succinyl-CoA(pN) C24H41N7O17P2S 793.1755 793.6316
552N 5′ diphosphate end p(pN) ϒ ϒ PO3 78.9585 78.972
550N 5′ hydroxyl end 5′-OH-N None None
N 5′ monophosphate end (pN) m m C5H7O10P2 288.9514 289.0521
255N 5′ nicotinamide adenine dinucleotide NAD(pN) Ξ Ξ C21H25N7O14P2 661.0935 661.4158
553N 5′ triphosphate end pp(pN) ϖ ϖ P3O9R 157.917 157.9439
47G 7-aminocarboxypropyl-demethylwyosine yW-86 ¥ ¥ C17O7N6H22 422.155 422.3986
347G 7-aminocarboxypropylwyosine yW-72 Ω Ω C18O7N6H24 436.1706 436.4256
348G 7-aminocarboxypropylwyosine methyl ester yW-58 C19O7N6H26 450.1863 450.4525
101G 7-aminomethyl-7-deazaguanosine preQ1tRNA C12O5N5H17 311.123 311.2982
100G 7-cyano-7-deazaguanosine preQ0tRNA φ φ C12O5N5H13 307.0917 307.2663
7G 7-methylguanosine m7G 7 7 C11O5N5H17 299.123 299.2867
79553N 7-methylguanosine cap (cap 0) m7Gpp(pN) © © C11H15N5O11P2 455.0243 455.2147
8A 8-methyladenosine m8A â â C11O4N5H15 281.1124 281.2719
02G N2,2′-O-dimethylguanosine m2Gm γ γ C12O5N5H17 311.123 311.2982
027G N2,7,2′-O-trimethylguanosine m2,7Gm æ æ C13H21N5O5 327.1543 327.3404
27G N2,7-dimethylguanosine m2,7G C12O5N5H19 313.1386 313.3136
279553N N2,7-dimethylguanosine cap (cap DMG) m2,7Gpp(pN) ® ® C12H17N5O11P2 469.04 469.2416
022G N2,N2,2′-O-trimethylguanosine m2,2Gm | | C13O5N5H19 325.1386 325.3252
227G N2,N2,7-trimethylguanosine m2,2,7G C13O5N5H21 327.1543 327.3404
2279553N N2,N2,7-trimethylguanosine cap (cap TMG) m2,2,7Gpp(pN) C13H19N5O11P2 483.0556 483.2685
22G N2,N2-dimethylguanosine m2,2G R R C12O5N5H17 311.123 311.2982
2G N2-methylguanosine m2G L L C11O5N5H15 297.1073 297.2712
04C N4,2′-O-dimethylcytidine m4Cm λ λ C11O5N3H17 271.1168 271.2737
044C N4,N4,2′-O-trimethylcytidine m4,4Cm β β C12O5N3H19 285.1325 285.3007
44C N4,N4-dimethylcytidine m4,4C μ μ C11O5N3H17 271.1168 271.2737
042C N4-acetyl-2′-O-methylcytidine ac4Cm C12O6N3H17 299.1117 299.284
42C N4-acetylcytidine ac4C M M C11O6N3H15 285.0961 285.257
4C N4-methylcytidine m4C ν ν C10O5N3H15 257.1012 257.2467
06A N6,2′-O-dimethyladenosine m6Am χ χ C12O4N5H17 295.1281 295.2989
066A N6,N6,2′-O-trimethyladenosine m6,6Am η η C13O4N5H19 309.1437 309.3259
66A N6,N6-dimethyladenosine m6,6A ζ ζ C12O4N5H17 295.1281 295.2989
60A N6-(cis-hydroxyisopentenyl)adenosine io6A ` ` C15O5N5H21 351.1543 351.3632
64A N6-acetyladenosine ac6A C12O5N5H15 309.1073 309.2822
67A N6-formyladenosine f6A Ϩ Ϩ C11H13N5O5 295.0917 295.2549
65A N6-glycinylcarbamoyladenosine g6A C13O7N6H16 368.108 368.3066
68A N6-hydroxymethyladenosine hm6A Ϫ Ϫ C11H15N5O5 297.1073 297.2708
63A N6-hydroxynorvalylcarbamoyladenosine hn6A C16O8N6H22 426.1499 426.3868
61A N6-isopentenyladenosine i6A + + C15O4N5H21 335.1594 335.3639
662A N6-methyl-N6-threonylcarbamoyladenosine m6t6A E E C16O8N6H22 426.1499 426.3868
6A N6-methyladenosine m6A = = C11O4N5H15 281.1124 281.2719
62A N6-threonylcarbamoyladenosine t6A 6 6 C15O8N6H20 412.1343 412.3598
10G (base) Qbase Qbase C12O3N5H15 277.1175 277.2836
A adenosine A A A C10O4N5H13 267.0968 267.2449
20C agmatidine C+ ¿ ¿ C14H25N7O4 355.1968 355.3973
2551N alpha-dimethylmonophosphate cap mm(pN) C7H14O10P2 320.0062 320.1297
1551N alpha-methylmonophosphate cap m(pN) C6H12O10P2 305.9906 306.1028
103G archaeosine G+ ( ( C12H16N6O5 324.1182 324.2965
69A cyclic N6-threonylcarbamoyladenosine ct6A e e C15O7N6H18 394.1237 394.3442
C cytidine C C C C9O5N3H13 243.0855 243.2197
8U dihydrouridine D D D C9O6N2H14 246.0852 246.2203
102G epoxyqueuosine oQtRNA ς ς C17O8N5H23 425.1547 425.3991
104G galactosyl-queuosine galQtRNA 9 9 C23O12N5H33 571.2126 571.5423
1553N gamma-methyltriphosphate cap mpp(pN) § § CH3O6P2 172.9405 172.9787
105G glutamyl-queuosine gluQtRNA C22O10N6H30 538.2023 538.5155
G guanosine G G G C10O5N5H13 283.0917 283.2442
GN guanosine added to any nucleotide pG(pN) none none C10H13N5O8P 362.0502 362.2159
9553N guanylylated 5′ end (cap G) Gpp(pN) ϑ ϑ C10H12N5O14P3 440.0008 440.1799
2165A hydroxy-N6-threonylcarbamoyladenosine ht6A « « C15H20N6O9 428.1292 428.3541
34830G hydroxywybutosine OHyW C21O10N6H28 524.1867 524.4885
9A inosine I I I C10O5N4H12 268.0808 268.2295
42G isowyosine imG2 C14O5N5H17 335.123 335.3202
106G mannosyl-queuosine manQtRNA 8 8 C23O12N5H33 571.2126 571.5423
3480G methylated undermodified hydroxywybutosine OHyWy y y C19H26N6O8 466.1812 466.4511
342G methylwyosine mimG C15O5N5H19 349.1386 349.3472
34832G peroxywybutosine o2yW W W C21O11N6H28 540.1816 540.4878
100G (base) preQ0base preQ0base ψ ψ C7O1N5H5 175.0494 175.1501
101G (base) preQ1base preQ1base C7O1N5H9 179.0807 179.182
9U pseudouridine Y P P C9O6N2H12 244.0695 244.2043
10G queuosine QtRNA Q Q C17O7N5H23 409.1597 409.3998
3470G undermodified hydroxywybutosine OHyWx š š C18O8N6H24 452.1655 452.4242
0X unknown methylated base Xm Î Î - 0.0 0.0
X unknown modification xX @ @ - 0.0 0.0
?A unknown modified adenosine xA H H - 0.0 0.0
?C unknown modified cytidine xC < < - 0.0 0.0
?G unknown modified guanosine xG ; ; - 0.0 0.0
?U unknown modified uridine xU N N - 0.0 0.0
unknown nucleotide residue N . . - 0.0 0.0
U uridine U U U C9O6N2H12 244.0695 244.2043
502U uridine 5-oxyacetic acid cmo5U V V C11O9N2H14 318.0699 318.2403
503U uridine 5-oxyacetic acid methyl ester mcmo5U υ υ C12O9N2H16 332.0856 332.2672
3483G wybutosine yW Y Y C21O9N6H28 508.1918 508.4892
34G wyosine imG C14O5N5H17 335.123 335.3202