Overview of the MODOMICS Database

MODOMICS is the first comprehensive database system for biology of RNA modification. It integrates information about the chemical structure of modified nucleosides, their localization in RNA sequences, pathways of their biosynthesis and enzymes that carry out the respective reactions (together with their protein cofactors). Also included are the protein sequences, the structure data (if available), selected references from scientific literature, and links to other databases allowing to obtain comprehensive information about individual modified residues and proteins involved in their biosynthesis.

The MODOMICS database contains the following types of items:

Modifications, Reactions, Proteins and snoRNA tables can be downloaded in text format using the “Display as ASCII” option.


When using Modomics, please cite:

Machnicka MA, Milanowska K, Osman Oglu O, Purta E, Kurkowska M, Olchowik A, Januszewski W, Kalinowski S, Dunin-Horkawicz S, Rother KM, Helm M, Bujnicki JM, Grosjean H
MODOMICS: a database of RNA modification pathways: 2012 update
Nucleic Acids Res 2013 Jan 1;41(D1): D262-D267

Czerwoniec A, Dunin-Horkawicz S, Purta E, Kaminska KH, Kasprzak J, Bujnicki JM, Grosjean H, Rother K
MODOMICS: a database of RNA modification pathways. 2008 update
Nucleic Acids Res 2009 Jan;37(Database issue):D118-21. [Epub 2008 Oct 14]

Dunin-Horkawicz S, Czerwoniec A, Gajda MJ, Feder M, Grosjean H, Bujnicki JM.
MODOMICS: a database of RNA modification pathways.
Nucleic Acids Res. 2006 Jan 1;34(Database issue):D145-9.