Reagent and protecting group Summary



IUPAC Name triisopropyloxymethyl
Protecting group 2'-ribose
Deprotection fluoride labile
Synthesis reagent triisopropyloxymethyl chloride

Can be found in the following building blocks:

1-methyladenosine (BB2) 15763-06-1
1-methylguanosine (BB3) 2140-65-0
1-methylinosine 2140-73-0
3-methyluridine 2140-69-4
5-methylcytidine (BB3) 2140-61-6
5-methyluridine (BB2) 1463-10-1
N2,N2-dimethylguanosine (BB2) 2140-67-2
N2,N2-dimethylguanosine (BB3) 2140-67-2
N2-methylguanosine 2140-77-4
N2-methylguanosine (BB3) 2140-77-4
N4-methylcytidine 10578-79-7
N6,N6,2'-O-trimethyladenosine 30891-53-3
N6-acetyladenosine (BB1) 16265-37-5
N6-isopentenyladenosine 7724-76-7
N6-isopentenyladenosine (BB3) 7724-76-7
N6-methyladenosine 1867-73-8
N6-methyladenosine (BB4) 1867-73-8
N6-threonylcarbamoyladenosine (BB3) 24719-82-2
dihydrouridine (BB2) 5627-05-4
inosine (BB2) 58-63-9
pseudouridine (BB3) 1445-07-4
wybutosine 55196-46-8


Title Authors Journal Details PubMed Id DOI
The synthesis of 2'-O-[(Triisopropylsilyl)oxy] methyl (TOM) phosphoramidites of methylated ribonucleosides (m1G, m2G, m22G, m1I, m3U, m4C, m6A, m62A) for use in automated RNA solid-phase synthesis HÖBARTNER Claudia ; KREUTZ Christoph ; FLECKER Elke ; OTTENSCHLÄGER Elke ; PILS Werner ; GRUBMAYR Karl ; MICURA Ronald ; Monatshefte fuer Chemie [details] - -
Synthesis of 2′-O-[(Triisopropylsilyl)oxy]methyl (= tom)-Protected Ribonucleoside Phosphoramidites Containing Various Nucleobase Analogues Porcher S, Pitsch S. HELVETICA CHIMICA ACTA [details] - 10.1002/hlca.200590209

Last modification of this entry: 2012-06-01 11:10:19.426826
Edited by a user: mark
Edited content: Changed papers.